Topbp1 phf8

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August undefined, 2024

Web28. jan 2024 · Interaction between TopBP1 and PHF8 is cell-cycle and phosphorylation dependent. ( A) The interaction between TopBP1 and PHF8 is cell-cycle dependent. HeLa … Web1. apr 2024 · Here, we showed PHF8-promoted TOPBP1 is clinically associated with breast tumorigenesis and patient survival. Mammary gland tumors from grow slowly and exhibit …

Disrupting PHF8-TOPBP1 connection elicits a breast tumor …

Web1. dec 2024 · Clearly further work will be required to fully delineate the role of PHF8 in the complex functions of TOPBP1. Although not an enzyme itself, but rather a regulator of one - the protein phosphatase PP2A inhibitor CIP2A has recently been characterised as an essential TOPBP1 interactor [69], [70]. WebBioGRID Interaction 3110875 Between PHF8 And TOPBP1. Toggle navigation. Bio GRID 4.4 freshwater diatom image

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1

WebMonoclonal Antibody for studying TOPBP1. Cited in 4 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, TopBP1 (D8G4L) Rabbit Monoclonal Antibody (CST #14342) is ready to ship. Web3. okt 2024 · PHF8 is phosphorylated by CK2, which regulates binding of PHF8 to TopBP1. Importantly, PHF8 regulates TopBP1 protein level by preventing its ubiquitination and … Web1. máj 2024 · Mechanistically, PHF8 interacts with and demethylates TOPBP1 (DNA topoisomerase 2-binding protein 1), an essential allosteric activator of ATR, under … father faucher boise

PHF8-promoted TOPBP1 demethylation drives ATR activation and …

WebDisrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics. Authors - Shuai Ma. View Article. mouse: IF: J Genet Genomics. The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis. Authors - Yushan Li. Web23. apr 2024 · Reliable and accurate glucose detection in biological samples is of great importance in clinical diagnosis and medical research. Chemical probes are advantageous in simple operation and flexible design, especially for the development of fluorescent probes. Anthracene-based diboronic acid (P-DBA) has … father fats stevens point menuWebBioGRID Interaction 2973252 Between PHF8 And TOPBP1. Toggle navigation. Bio GRID 4.4 father fats stevens point wisconsin

"Web1. apr 2024 · Here, we showed PHF8-promoted TOPBP1 is clinically associated with breast tumorigenesis and patient survival. Mammary gland tumors from Phf8 grow slowly and … " - Topbp1 phf8

Topbp1 phf8

Synthesis of Diboronic Acid-Based Fluorescent Probes for the

WebPHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability Shuai Ma, Cheng Cao, Shiyou Che, Yuejiao Wang, Dongxue Su, Shuai Liu, Wenchen Gong, Ling Liu, Jixue Sun, Jiao Zhao, Qian Wang, Nan Song, Tong Ge, Qiushi Guo, Shanshan Tian, Charlie Degui Chen, Tao Zhang, Ju Wang, Xiang Ding, Web7. feb 2024 · Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during Mitosis. The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis. Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics.

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Web14. okt 2024 · Lysine Demethylase PHF8-Promoted TOPBP1 Demethylation Drives ATR Activation and Contributes to Breast Tumorigenesis Number of pages: 131Posted: 14 Oct 2024 http://tjmuch.xuezheku.com/Document/Detail/03B2F8F72127E5C382F608838429034B.html

Web接下来我们发现PHF8和TopBP1在体内、体外存在相互作用,并且PHF8是通过其C端的22个保守的氨基酸与TopBP1的BRCT 7+8结构域相互作用。 PHF8负责与TopBP1相互作用的22aa以及它的去甲基化酶活性都能影响ATR信号的活化,并且PHF8与TopBP1相互作用的部分以及它的去甲基化酶活性也影响了TopBP1的募集;在临床组织样本分析中,我们发现PHF8 … Genomic stability following DNA damage depends on the coordination of cell cycle checkpoint control and proper DNA repair. ATR (ataxia telangiectasia mutated- and Rad3-related) … Zobraziť viac Human TopBP1 is a key scaffold protein that can interact with many other proteins and play essential roles in a diverse range of cellular pathways, including DNA replication … Zobraziť viac We would like to thank all our colleagues in the Gong laboratory for insightful discussion and technical assistance. We want to thank Dr … Zobraziť viac

Web27. okt 2024 · Mammalian TopBP1 has been reported to be involved in a variety of different cellular processes, such as regulating the DNA replication checkpoint as well as the mitotic checkpoint and its progression. Web1 21 340 25496 321 2.2944803032966101 2.4179719683946699e-6. 1 234 11093 25496 321 0.74455657479452997 2.4919684522412299e-23. 1 153 6503 25496 321 0.90205195090794499

WebDownload scientific diagram Interaction between TopBP1 and PHF8 is cell-cycle and phosphorylation dependent. (A) The interaction between TopBP1 and PHF8 is cellcycle …

Web26. feb 2024 · CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication Authors Haihua Feng 1 , Jingchen Lu 1 2 , Xiaotian Song 1 , Angkana Thongkum 1 , Fan Zhang 1 , Lihong Lou 1 , Ofer Reizes 3 , Alexandru Almasan 1 , Zihua Gong 1 4 Affiliations freshwater diatoms speciesWebNational Center for Biotechnology Information father federico palmaWeb21. mar 2024 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Ataxia-Telangiectasia and Seckel … father federline obituaryWebBioGRID Interaction 2973250 Between TOPBP1 And PHF8. Toggle navigation. Bio GRID 4.4 father feast dayWeb27. máj 2024 · TOPBP1含有多组成对出现的BRCT（BRCA1 C-terminal）结构域，它们负责识别不同磷酸化形式的配体蛋白，决定了TOPBP1在复制起始或复制压力应答中的特异性工作模式。然而，在HR倾向性的DSBs染色质区域，TOPBP1是如何被募集的尚不清楚。作者发现HTATSF1（HIV Tat-specific factor 1）在复制活跃细胞中高表达，是S期TOPBP1相互作用 … father federico cinoccaWeb6. dec 2024 · Histone demethylase PHF8 promotes cell growth and metastasis of non-small-cell lung cancer through activating Wnt/beta-catenin signaling pathway. Disrupting PHF8 … father federicoWeb21. júl 2024 · The SLX1-SLX4 structure-specific endonuclease complex is involved in processing diverse DNA damage intermediates, including resolution of Holliday junctions, collapse of stalled replication forks and removal of DNA flaps. The nuclease subunit SLX1 is inactive on its own, but become activated upon bi … father faustus