Phosphopantetheine-binding protein
WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl … WebOct 3, 2003 · is synthesized by the addition of cysteine to 4′-phosphopantothenate and, in the next step, P PC is decarboxylated to 4′-phosphopantetheine. 4′-phosphopantetheine is converted to coenzyme A by the enzymes 4′-phosphopantetheine adenylyltransferase and dephospho-CoA kinase ( Fig. 1 ).
Phosphopantetheine-binding protein
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WebMay 30, 2024 · FIGURE 2.(A) Structural superposition of apo Mab PPAT in complex with feed-back inhibitor CoA (grey), PDB code 7YXZ and product dpCoA (green), PDB code 5O08, showing conformational differences in the enzyme and ligand binding mode.(B) The pantetheine moiety of CoA adopts a similar conformation to that of dpCoA. However, the … WebThe OUROBOROS and SAMSARA proteins heterodimerise in a similar manner to TALE HD TF life cycle regulators in the green lineage. These observations demonstrate that TALE-HD-TF-based life cycle regulation systems have an extremely ancient origin, and that these systems have been independently recruited to regulate sporophyte developmental ...
WebLegend. Settings. Analysis WebMar 8, 2024 · A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and …
WebThe OUROBOROS and SAMSARA proteins heterodimerise in a similar manner to TALE HD TF life cycle regulators in the green lineage. These observations demonstrate that TALE-HD-TF-based life cycle regulation systems have an extremely ancient origin, and that these systems have been independently recruited to regulate sporophyte developmental ... WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins ... (for 4′-phosphopantetheine 10). The binding of dephospho-CoA was also shown to be competitive with both ATP and phosphopantetheine, whereas ...
WebThe mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound …
WebOct 23, 2013 · The results suggest that some type I domains covalently incorporated in multidomain contexts possess potential protein binding sites missing in the equivalent regions of their respective structural templates. ... This 1136 residue long sequence is atypical since it does not possess a recognizable phosphopantetheine binding domain … port aransas texas sandcastle resortWebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement mechanism, where both the substrates are positioned in a single line. This results in a short lived intermediate pentacovalent transition state. port aransas texas rental homes for vacationWebProteomics of Streptococcus mutans to Reveal the Antibiofilm Formation Mechanism of Ag/ZnO Nanocomposites with Light-Emitting Diode Radiation irish month namesWebPhosphopantetheine-binding protein (Pectobacterium carotovorum PC1) - STRING interaction network Nodes: Network nodes represent proteins splice isoforms or post … port aransas texas sandfest 2021WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … port aransas texas property for saleWebJan 3, 2024 · Using E. coli LipB as a prototype, we show that the enzyme mainly recognizes the 4’-phosphopantetheine tethered acyl-chain of its donor substrate, and weakly binds the apo-acyl carrier protein. It can accept octanoate-from its own ACP, noncognate ACPs, as well as C 8 -CoA. irish monthly boxWebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. port aransas texas rentals beachfront