Phospho-acss2
WebNutritional stresses, which restrict acetyl-CoA production from glucose or acetate uptake, result in AMPK-mediated phosphorylation and nuclear translocation of ACSS2. ACSS2 binds to TFEB, translocates to lysosomal and autophagosomal gene promoter regions, and incorporates acetate from histone acetylation turnover to locally produce acetyl-CoA for … WebJan 21, 2024 · We interrogate whether ACSS2 can facilitate the local transfer of acetyl groups. Our results point to direct transfer of intact acetate that is mediated by ACSS2, underscoring a critical function of acetate transfer in using local and nuclear acetate pools for histone acetylation and rapid transcriptional activation.
Phospho-acss2
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WebSep 18, 2024 · Acss2 Deletion Protects Against Lipid Deposition and Obesity. To gain insight into the normal physiological function of ACSS2, we compared Acss2 -null mice with …
WebDownload scientific diagram Targeting OGT or CDKs blocks GBM growth ex vivo a Representative images depicting tumor growth in organotypic brain slices derived from mice intracranially injected ... WebSep 15, 2024 · The invention relates to novel compositions, combinations and methods relating to compounds which inhibit EZH2 and their uses for treating and/or preventing tumors associated with methyltransferase EZH2. More specifically the invention relates to synergistic bi-therapy compositions for use in a method of treating and/or preventing …
WebAcss2 −/ mice fed a chow diet (SI Appendix, Fig. S3 A–C). Taken together, these results indicate that the absence of ACSS2 im-pedes fat deposition and obesity associated with high dietary-fat intake. Acss2 Deletion Protects Against Hepatic Steatosis. Insulin resistance and hepatic steatosis are two common pathological phenotypes WebNational Center for Biotechnology Information
WebDeacetylates ACSS2 leading to its activation, and HMGCS1. Involved in liver and muscle metabolism. ... All lanes : Anti-SIRT1 (phospho T530) antibody [EPNCIR153] (ab156585) at 1/1000 dilution Lane 1 : 293T cell lysates Lane 2 : 293T cell lysates treated with Calyculin A Lysates/proteins at 10 µg per lane. Secondary
WebFeb 6, 2024 · ACSS2, endogenous ACSS2 protein; His-ACSS2, reintroduced exogenous ACSS2 protein; L, long exposure; S, short exposure. (C) HCMV growth was rescued by the reintroduction of ACSS2-resistant guide RNA. Two days after reintroduction of His-ACSS2-R, cells were serum-starved overnight and were infected with HCMV at an MOI of 3. Viruses … shared insured progressiveWebJul 7, 2024 · ACSS2 has been found to primarily undergo translocation from the cytoplasm to the nucleus . ACSS2 translocation is tightly connected with hormonal and transcription … pool stores albany gaWebThis gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl - … pool stores clayton ncWebNov 12, 2024 · ACSS2 is the only known enzyme that can recycle acetate derived from deacetylation reactions in the cytoplasm and nucleus of cells, including both protein and metabolite deacetylation reactions. As such, ACSS2 can recycle acetate derived from histone deacetylase reactions as well as protein deacetylation reactions mediated by … shared interface asaWebIn the nucleus, ACSS2 binds to transcription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from … pool store orland parkWebNov 23, 2024 · ACSS2 enables cholesterol synthesis in the cytoplasm, which is trafficked to the surface to provide mechanical tenacity. GM3-IRE1-sXBP1-ACSS2-cholesterol axis is … shared internallyWebMar 1, 2024 · The standard compounds, including pyruvate, lactate, alanine, acetate, succinate, glucose, palmitate, glycine, glutamate, isoleucine, valine, leucine, and … shared interaction