WebbIACS-9571 is a high-affinity, potent TRIM24/BRPF1 bromodomain (BrD) inhibitor (Kd = 1.3/2.1 nM by DiscoveRx) with good selectivity over other BrDs (BRPF2/3 Kd = 12/27 … WebbArticle Snippet: Figure 3 IACS-9571 causes synergistic activation T cell signaling agonists. ( A – H ) Jurkat Tat mHIV-Luciferase cells were treated with the indicated latency reversing agent, with or without 10 µM IACS-9571. Techniques: Luciferase, Transduction, Expressing, Plasmid Preparation, Incubation, Standard Deviation

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1

Webb17 juni 2024 · IACS-9571 reactivates HIV-1 in T cell lines bearing multiple different provirus models of HIV-1 latency. Additionally, treatment with this TRIM24 bromodomain inhibitor encourages productive HIV-1 expression in newly infected cells and inhibits formation of immediate latent transcriptionally repressed provirus. IACS-9571 synergizes with PMA ... WebbIACS-9571 is a high-affinity, potent TRIM24/BRPF1 bromodomain (BrD) inhibitor (Kd = 1.3/2.1 nM by DiscoveRx) with good selectivity over other BrDs (BRPF2/3 Kd = 12/27 … team 1 image

IACS-9571 ≥99%(HPLC) TRIM24/BRPF1 inhibitor

WebbIACS-9571 has low nanomolar affinities for TRIM24 and BRPF1 (ITC Kd = 31 nM and 14 nM, respectively). With its excellent cellular potency (EC50 = 50 nM) and favorable pharmacokinetic properties (F = 29%), IACS-9571 is a high-quality chemical probe for the evaluation of TRIM24 and/or BRPF1 bromodomain function in vitro and in vivo. Webbsitu cell extraction, TRIM24, Bromodomain inhibitor, IACS‑9571, IACS‑6558. Zhan et al. Epigenetics & Chromatin Page 3 of 19 to identify small-molecule inhibitors of recombinant purified bromodomains. The identification of sufficiently tight-binding peptides is usually a key challenge when WebbIACS-9571 is a high-affinity, potent TRIM24/BRPF1 bromodomain (BrD) inhibitor (Kd = 1.3/2.1 nM by DiscoveRx) with good selectivity over other BrDs (BRPF2/3 Kd = 12/27 … team 1 jake paul wallpaper for computer